The aim of this study was to evaluate the hepatoprotective effects of methanolic extract of Eclipta alba (MEEA) Linn in carbon tetrachloride (CCl4)-treated rats. Animals were pretreated with the MEEA (200 & 400 mg/kg body weight) for one week and then challenged with CCl4 (1 ml/kg bw) in olive oil (1:1, v/v) on 7th day. Serum marker enzymes (ALP, AST, ALT and Total Bilirubin) were estimated in all the study groups. Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and Total Bilirubin were tested in both CCl4 treated and extract treated groups. CCl4 has significantly (P<0.001) enhanced the AST, ALT and ALP levels in liver. Treatment of MEEA (200 & 400 mg/kg) produced significant (P<0.001) hepatoprotective effects as evidenced by decreased serum enzyme activities, AST, ALT, ALP and serum Bilirubin and an almost normal histological architecture of the liver, in treated groups, compared to the controls. The experimental results indicate that, MEEA has excellent hepatoprotective effect. A similar experimental result was also observed by histological parameters.
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